|
Urinary Calculi
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Renal inter-alpha-trypsin inhibitor heavy chain 3 increases in calcium oxalate stone-forming patients.
|
17898697 |
2007 |
|
Unipolar Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5).
|
28989100 |
2018 |
|
Schizophrenia
|
0.440 |
Biomarker
|
disease |
PSYGENET |
After combining the new schizophrenia data with those of the PGC, variants at three loci (ITIH3/4, CACNA1C and SDCCAG8) that had not previously been GWS in schizophrenia attained that level of support.
|
22614287 |
2013 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4.
|
21926972 |
2011 |
|
Schizophrenia
|
0.440 |
Biomarker
|
disease |
BEFREE |
The successful replication of this finding in a different ethnic group provides stronger evidence for the association between schizophrenia and ITIH3/4.
|
26206863 |
2015 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Common single nucleotide polymorphisms (SNPs) in or near the inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) gene have been repeatedly associated with schizophrenia and related psychiatric disorders in genome-wide association studies.
|
27396837 |
2016 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.
|
30626913 |
2019 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Schizophrenia
|
0.440 |
Biomarker
|
disease |
BEFREE |
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC.
|
22614287 |
2013 |
|
Schizophrenia
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
|
29483656 |
2018 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains.
|
11807786 |
2002 |
|
Myocardial Infarction
|
0.110 |
GeneticVariation
|
disease |
LHGDN |
Furthermore, we found expression of the ITIH3 protein in the vascular smooth muscle cells and macrophages in the human atherosclerotic lesions, suggesting ITIH3 SNP to be a novel genetic risk factor of MI.
|
17211523 |
2007 |
|
Myocardial Infarction
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found expression of the ITIH3 protein in the vascular smooth muscle cells and macrophages in the human atherosclerotic lesions, suggesting ITIH3 SNP to be a novel genetic risk factor of MI.
|
17211523 |
2007 |
|
Myocardial Infarction
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Furthermore, we found expression of the ITIH3 protein in the vascular smooth muscle cells and macrophages in the human atherosclerotic lesions, suggesting ITIH3 SNP to be a novel genetic risk factor of MI.
|
17211523 |
2007 |
|
Mood Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
These results provide experimental support for the role of ITIH1/ITIH3 in the development of mood disorders.
|
29987918 |
2019 |
|
Mental disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1.
|
24373612 |
2014 |
|
Mental disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Several genome-wide association studies and case-control studies regarding psychiatric disorders have identified ITIH3 and ITIH4 single nucleotide polymorphisms (SNPs).
|
29992445 |
2018 |
|
Mental disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Common single nucleotide polymorphisms (SNPs) in or near the inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) gene have been repeatedly associated with schizophrenia and related psychiatric disorders in genome-wide association studies.
|
27396837 |
2016 |
|
Major Depressive Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
A mega-analysis of genome-wide association studies for major depressive disorder.
|
22472876 |
2013 |
|
Major Depressive Disorder
|
0.110 |
Biomarker
|
disease |
BEFREE |
Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5).
|
28989100 |
2018 |